Benzo[g]chromene-5,10-diones (chromene-diones) have been synthesized by an efficient, simple and green one-pot domino protocol by multi-component condensation of 2-hydroxy-1,4-naphthoquinone with aldehydes and (E)-N-methyl-1-(methylthio)-2-nitroethenamine in the presence of poly(oligoethylene glycol methacrylate)-g-supported layered double hydroxides (LDHs-g-POEGMA), under solvent-free condition. The significant features of this “green” reaction include short reaction time, high product yields in pure form, eco-friendly method; avoid the toxic solvents and no need for purification of the product by column chromatography. Furthermore the catalyst (LDHs-g-POEGMA) is reused for several consecutive runs without losing its catalytic activity.