Synthesis of 2-amino-4H-chromen-4-ylphosphonates has been accomplished by the one-pot three-component reaction of salicylaldehyde, malononitrile/ethylcyanoacetate and dialkyl phosphites were carried out in the presence reusable deep eutectic solvent (DES) under mild conditions. The applicability of DES for the synthesis of 2-amino-4H-chromenes also has been described. The advantages of this methods is mild reaction conditions, simple work-up procedure, and use of DES as an inexpensive and green solvent provides an economical protocol for the preparation of important biological active phosphorus-containing compounds. |