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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 20일 (금요일) 13:00~14:30 |
| Code |
ORGN.P-261 |
| Subject |
Derivatization of Peptoids Using Chan-Lam Reaction |
| Authors |
Jihyun Song, Yong-Uk Kwon*
Department of Chemistry and Nanoscience, Ewha Womans University, Korea
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| Abstract |
Peptides are representative biomolecules that possess various physiological activities in vivo. Thus, they are attractive chemical tools for chemical biology and drug development. However, peptides have unwanted drawbacks including a proteolytic degradation, insufficient cell permeability, etc. To overcome these defects, many different types of peptidomimetics have been developed. Among them, peptoids emerged as valuable molecular tools. They have many advantages such as easy synthesis, tremendous diversity in library construction, resistance to proteolytic degradation and improved cell permeability. Hence, peptoids have attracted great attention to many chemists, pharmacologists, biologists, etc.
The N-arylation/O-arylation methodology using Chan-Lam cross coupling reaction is a powerful synthetic tool. Therefore, we have employed Chan-Lam reaction in solid phase synthesis for efficient functionalization of peptoids to maximize their diversity. It was also applied to develop cyclic peptoids as a new macrocyclization method. In this presentation, we will report herein synthetic studies for the interesting derivatization of peptoids using Chan-Lam reaction on solid-phase. |
| E-mail |
song-j-h@hanmail.net |
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120th General Meeting of the KCS