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| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 19일 (목요일) 11:00~12:30 |
| Code |
BIO.P-240 |
| Subject |
Redox-tuning of Small Molecules to Develop Chemical Regulators for Multiple Pathogenic Elements in Alzheimer’s Disease |
| Authors |
Jiyeon Han, Hyuck Jin Lee1, Jaeheung Cho2, Junghyun Chae3,*, Mi Hee Lim*
Department of Chemistry, Ulsan National Institute of Science and Technology, Korea
1School of Life Sciences, Ulsan National Institute of Science and Technology, Korea
2Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science & Technology, Korea
3Department of Chemistry, Sungshin University, Korea
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| Abstract |
Various pathogenic factors [e.g., metal ions, metal-free amyloid-β (Aβ), metal-bound Aβ (metal–Aβ), free radicals] are observed to be inter-related leading to the pathogenesis of Alzheimer’s disease (AD). In order to regulate their complex interactions, the development of chemical reagents targeting such multiple components has received significant attention. Herein, we report that tuning the redox properties of small molecules is key to inventing effective chemical regulators towards the actions of pathological elements found in AD. In our newly prepared chemical series, compound 1 with the lowest oxidation potential, is able to modulate the aggregation of both metal-free Aβ and metal–Aβ as well as scavenge free radicals. Our biochemical and biophysical studies illuminate that the noticeable reactivities of 1 towards metal-free Aβ, metal–Aβ, and free radicals can be achieved via peptide oxidation/degradation and ligand oxidation. Compound 2, which indicates a relatively higher oxidation potential than 1, alters Cu(II)–Aβ42 aggregation, whereas compound 3, which is hardly oxidized, shows no reactivity with metal-free and metal-treated Aβ as well as free radicals. Overall, our studies demonstrate that the redox properties of small molecules can determine their regulatory reactivities against multiple factors related to AD pathogenesis. |
| E-mail |
jiyeonnn93@gmail.com |
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120th General Meeting of the KCS