120th General Meeting of the KCS

Type Poster Presentation
Area Life Chemistry
Room No. Exhibition Hall 2+3
Time 10월 19일 (목요일) 11:00~12:30
Code BIO.P-241
Subject A catecholamine neurotransmitter towards pathogenic features found in Alzheimer’s disease
Authors Eunju Nam, Jiyeon Han, Mi Hee Lim*
Department of Chemistry, Ulsan National Institute of Science and Technology, Korea
Abstract Information on interactions between dopamine and multiple pathogenic factors of Alzheimer’s disease (AD) [i.e., amyloid-β (Aβ), metals, reactive oxygen species (ROS)] is very limited; thus, despite a suggested link of dopamine to AD pathology, it is difficult to elucidate its influence on AD pathogenesis. Herein, we report dopamine’s direct interactions and reactivities with both metal-free Aβ and metal-bound Aβ, along with its effect on the activation of proteins capable of controlling inflammation as well as oxidative stress. Moreover, our studies of a new chemical library, designed through structural variations of dopamine, identified that dopamine’s oxidative cyclization with concomitant ROS production could be essential for controlling Aβ aggregation and Aβ-induced cytotoxicity. Detailed biochemical, biophysical, and biological investigations regarding how dopamine is able to modulate multiple AD pathogenic features will be presented. Our overall studies provide new insight into a novel role of a catecholamine neurotransmitter, dopamine, in AD pathology.
E-mail eunjunam@unist.ac.kr