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|
| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 19일 (목요일) 11:00~12:30 |
| Code |
BIO.P-244 |
| Subject |
Surface Structure of Amyloid beta (Aβ) Characterized by Atomic Force Microscopy
|
| Authors |
jihyun Yoon, Joon Won Park*
Department of Chemistry, Pohang University of Science and Technology, Korea
|
| Abstract |
Alzheimer’s disease (AD) is one of the most prevalent severe degenerative neuronal diseases afflicting our elderly population. AD has been verified as a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) into the human brain. Aβ is considered to play a causal role in the development and progress of AD, but its molecular structure remains unclear.
Here, we have used AFM to reveal the surface structure of Aβ. The observed specific interaction between Aβ and both C/N-terminal specific antibody suggests a surface structure model in which both N-terminus and C-terminus are exposed at the surface.
|
| E-mail |
yoonjihyun@postech.ac.kr |
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120th General Meeting of the KCS