|
Type |
Symposium |
Area |
[SRC Symposium] Biomimetic Catalysis Based on Porous Platform (BCP2) |
Room No. |
Room 214 |
Time |
WED 15:00-: |
Code |
KCS4-4 |
Subject |
A catecholamine neurotransmitter towards pathogenic features found in Alzheimer’s disease |
Authors |
Eunju Nam, Mi Hee Lim* Department of Chemistry, Ulsan National Institute of Science and Technology, Korea |
Abstract |
Information on interactions between dopamine and multiple pathogenic factors of Alzheimer’s disease (AD) [i.e., amyloid-β (Aβ), metals, reactive oxygen species (ROS)] is very limited; thus, despite a suggested link of dopamine to AD pathology, it is difficult to elucidate its influence on AD pathogenesis. Herein, we report dopamine’s direct interactions and reactivities with both metal-free Aβ and metal-bound Aβ, along with its effect on the activation of proteins capable of controlling inflammation as well as oxidative stress. Moreover, our studies of a new chemical library, designed through structural variations of dopamine, identified that dopamine’s oxidative cyclization with concomitant ROS production could be essential for controlling Aβ aggregation and Aβ-induced cytotoxicity. Detailed biochemical, biophysical, and biological investigations regarding how dopamine is able to modulate multiple AD pathogenic features will be presented. Our overall studies provide new insight into a novel role of a catecholamine neurotransmitter, dopamine, in AD pathology. |
E-mail |
eunjunam@unist.ac.kr |
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