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| Type |
Oral Presentation |
| Area |
Oral Presentations of Young Scholars in Organic Division |
| Room No. |
Room 304+305+306 |
| Time |
THU 09:00-: |
| Code |
ORGN.O-1 |
| Subject |
Introduction of a New Hydroxybenzyne Precursors Induced by 1,3-Brook Rearrangement |
| Authors |
Yong-Ju Kwon, Wonsuk Kim1,*
Department of Chemistry and Nano Science, Ewha Womans University, Korea
1Chemistry Department of Nano-Science, Ewha Womans University, Korea
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| Abstract |
Benzynes are highly strained and reactive alkynes and derived from an aromatic ring by removal of two ortho substituents. Because it has great activity and usefulness, a lot of attempt to make benzyne formation have been reported and especially, the method using silyaryl triflate in the presence of fluoride source has been employed. Herein, we report the design, synthesis and achievements of a new type of benzyne precursor which is capable of highly reactive benzyne intermediate induced by 1,3-silyl group migration on the aryl moiety. We would use this base-promoted benzyne generation method for the nucleophilic addition reaction and cycloaddition reaction and obtained meta-regioselective compounds in good to excellent yields. We also investigated plausible mechanism through previous reported method and crossover experiment.
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| E-mail |
rdjwkd@naver.com |
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120th General Meeting of the KCS