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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 20일 (금요일) 13:00~14:30 |
| Code |
ORGN.P-275 |
| Subject |
Metal-Free Esterification of Aldehyde Using Bromo Source under Mild Condition |
| Authors |
Hee-Kwon Kim
Department of Nuclear Medicine, Chonbuk National University Medical School and Hospital, Korea |
| Abstract |
Ester is common chemical functional group found in various natural products, pharmaceuticals, and polymers. The ester unit has been utilized to a variety of organic synthesis fields. Necleophilic substitution reaction of carboxylic acids with alcohols is widely used methods for the synthesis of esters. In addition, oxidation of aldehydes to esters using hemiacetal intermediate is one of the useful methods. However, the synthetic methods have a weakness such as steric effect and instability of intermediate. Herein, novel method for the conversion of aldehydes to esters is described. In the novel synthetic method, acyl bromide intermediates was prepared by the treatment of aldehydes with bromo source, and then were reacted with various alcohols and phenols to give the corresponding esters with high yields under mild reaction condition. |
| E-mail |
hkkim717@gmail.com |
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120th General Meeting of the KCS