|
Type |
Symposium |
Area |
Current Trends in Organic Chemistry I: Unexpected Reactivity and Selectivity |
Room No. |
Room 304+305+306 |
Time |
THU 15:15-: |
Code |
ORGN1-5 |
Subject |
Site-Selectivite Catalytic C-H Functionalization: Design, Synthesis and Biological Evaluation of Novel Heterocycles |
Authors |
IN SU KIM School of Pharmacy, Sungkyunkwan University, Korea |
Abstract |
With considerable progress in medicinal chemistry, the construction of heterocycles has receiveed increasing attention in the past decades. In particular, N-heterocycles such as indoles, indolines, indazoles, and cinnolinones are widely found to be biologically relevant scaffold in natural products, pharmaceuticals, agrochemicals, and functional materials. Therefore, the directing group-assisted N-heterocycles synthesis via C-H bond activation is highly attractive in pharmaceutical industry.
Thus, we recently focused the construction of other N-heterocycles via tandem C-C and C-N bond formations followed by intramolecular cyclization. Moreover, our groups recently reported the synthesis and biological evaluation of novel heterocyclic molecules through Rh(III)-, Ru(II)- and Ir(III)-catalyzed C-H functionalizations of biologically relevant isoindolinones, xanthones, chromones, indolines, and etc.
We herein describe a brief summary of our recent works and present progress works on the synthesis and biological evaluation of heterocycles through Rh(III)-catalyzed C-H functionalization. Notably, we present the unexpected reactivity and selectivity on Rh(III)- and Ru(II)-catalyzed C-H functionalizations leading to the discovery of alternative reaction pathways. |
E-mail |
insukim@skku.edu |
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