120th General Meeting of the KCS

Type Symposium
Area Current Trends in Organic Chemistry I: Unexpected Reactivity and Selectivity
Room No. Room 304+305+306
Time THU 15:15-:
Code ORGN1-5
Subject Site-Selectivite Catalytic C-H Functionalization: Design, Synthesis and Biological Evaluation of Novel Heterocycles
Authors IN SU KIM
School of Pharmacy, Sungkyunkwan University, Korea
Abstract With considerable progress in medicinal chemistry, the construction of heterocycles has receiveed increasing attention in the past decades. In particular, N-heterocycles such as indoles, indolines, indazoles, and cinnolinones are widely found to be biologically relevant scaffold in natural products, pharmaceuticals, agrochemicals, and functional materials. Therefore, the directing group-assisted N-heterocycles synthesis via C-H bond activation is highly attractive in pharmaceutical industry. Thus, we recently focused the construction of other N-heterocycles via tandem C-C and C-N bond formations followed by intramolecular cyclization. Moreover, our groups recently reported the synthesis and biological evaluation of novel heterocyclic molecules through Rh(III)-, Ru(II)- and Ir(III)-catalyzed C-H functionalizations of biologically relevant isoindolinones, xanthones, chromones, indolines, and etc. We herein describe a brief summary of our recent works and present progress works on the synthesis and biological evaluation of heterocycles through Rh(III)-catalyzed C-H functionalization. Notably, we present the unexpected reactivity and selectivity on Rh(III)- and Ru(II)-catalyzed C-H functionalizations leading to the discovery of alternative reaction pathways.
E-mail insukim@skku.edu