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| Type |
Symposium |
| Area |
Current Trends in Organic Chemistry III: New Reactions and Methodology |
| Room No. |
Room 304+305+306 |
| Time |
FRI 15:30-: |
| Code |
ORGN3-3 |
| Subject |
Biosynthetically Inspired Total Syntheses of Complex Natural Products |
| Authors |
Sunkyu Han
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea |
| Abstract |
Despite an extensive history of natural products total synthesis, devising efficient synthetic strategies for complex secondary metabolites is still intellectually daunting and toilsome. As one means to facilitate the retrosynthetic endeavor, chemists have sought inspiration from the biosynthesis of natural products. We show how structural analysis of biosynthetically relevant natural products and the biosynthetic hypothesis of structurally relevant secondary metabolites can provide hints for the design of synthetic routes. We showcase the viability of this general approach by presenting total syntheses recently completed in our laboratory.1
References
1. (a) Jo, D.; Han, S. Org. Chem. Front. 2017, 4, 506. (b) Jeon, S.; Han, S. J. Am. Chem. Soc. 2017, 139, 6302. (c) Kang, T.; Jo, D.; Han, S. J. Org. Chem. 2017, ASAP.
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| E-mail |
sunkyu.han@kaist.ac.kr |
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120th General Meeting of the KCS