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| Type |
Symposium |
| Area |
Recent Trends in Organometallic Chemistry |
| Room No. |
Room 211+212+213 |
| Time |
FRI 15:20-: |
| Code |
INOR2-3 |
| Subject |
Cobalt-Catalyzed C–F Bond Borylation of Aryl Fluorides |
| Authors |
Eunsung Lee
Department of Chemistry, Pohang University of Science and Technology, Korea |
| Abstract |
Fluorine atoms can be found in a variety of organic molecules such as pharmaceuticals, agrochemicals, and polymeric materials. In line with an importance of fluorinated compounds, there have been significant advances on C−F bond formation for the past decades. However, unlike a development of C−F bond formation reactions, C−F bond functionalization has been limited to either highly activated C−F bonds or C−C bond formation. In 2015, C−F functionalization of unactivated fluoroarenes has been developed by the Marting group and the Niwa and Hosoya group demonstrating Ni-catalyzed defluoroborylation of fluoroarenes and its application to F-18 radiochemistry and further organic transformations. Although the methods are efficient and top-notched, there are still some limitations: high reaction temperatures, limited functionality-tolerance, and operational difficulty. In order to overcome the barriers, we have been explored Co-based catalysis and here we present cotalt-catalyzed unactivated aryl C-F bond borylation. This reaction can be set up under the air condition and do not require a presynthesized organometallic complex. A mild and practical Co-catalyzed borylation of various fluoroarenes enables a new reaction strategy in synthetic chemistry.
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| E-mail |
eslee@postech.ac.kr |
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120th General Meeting of the KCS