120th General Meeting of the KCS

Type Poster Presentation
Area Medicinal Chemistry
Room No. Exhibition Hall 2+3
Time 10월 19일 (목요일) 11:00~12:30
Code MEDI.P-299
Subject Synthesis of 6-hydroxy-4-oxo-1,2-dihydro-4H-pyrrolo[3,2,1- ij]quinoline-5-carboxylic acid derivatives as Potential Inhibitor of S. pneumoniae serotypes
Authors Srigouri Huddar, Chul Min Park1, Sunkyung Lee1,*
Medicinal Chemistry and pharmacology, University of Science & Technology, Korea
1Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Korea
Abstract Studies from USA, Europe and Asia reported that antibiotic resistance rates from 18% to 84% observed, were associated with the emergence of multidrug resistance in S. pneumoniae and will continue to make currently available antibiotics essentially ineffective. Discovery of new therapies for treating drug resistant pneumococcal infections is therefore, urgently needed. A series of 6-hydroxy-4-oxo-1,2-dihydro-4H-pyrrolo[3,2,1- ij]quinoline-5-carboxylic acid derivatives were prepared and evaluated for their inhibitory activities on three different types of Streptococcus pneumoniae serotypes; S. pneumoniae serotypes ATCC 49617TM (19F, wild type), ATCC BAA-1663TM (15B, drug resistant), and ATCC 700904TM (19A, erythromycin resistant). From this studies, we identified potent compounds on resistant strains as well as wild type. Reference 1.Identification of Antipneumococcal Molecules Effective Against Different Streptococcus pneumoniae Serotypes Using a Resazurin-Based High-throughput screen, Assay and Drug Development Technologies, 2017, 15(5), 198-209.
E-mail srigouri.huddar@gmail.com