|
|
| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-302 |
| Subject |
Combinatorial synthesis of Drug-like Pyrrolopyrimidine analogues with a High level of diversity in solution-phase |
| Authors |
Si Yeon Han, eunsil Lee1, Young Dae Gong*
Department of Chemistry, Dongguk University, Korea
1Medicinal Chemistry Laboratory, Dongguk University, Korea
|
| Abstract |
Pyrimidine based derivatives are known to have a broad spectrum of biological activities such as anti-cancer, antimicrobial, anti-inflammatory, antiviral activity. Furthermore, many researchers have conducted study about biological activity of pyrimidine scaffold since success of Gleevec(Imatinib). Recently, pyrrolopyrimidine is also identified as a potent MRP1 inhibitors which mediated Multidrug resistance and JAK3(Janus kinases 3) inhibitors. In this context, as a part of our on-going project aimed at a construction of small molecule library, we have tried to synthesize pyrrolopyrimidines equipped with diverse functional groups in combinatorial way. As a result, we’ve obtained numerous pyrrolopyrimidine derivatives in high yields and purities.
References
1. Sven Marcel Schmitt, Katja Stefan, Michael Wiese. Biochimica et Biophysica Acta 1859 (2017) 69–79 .
2. Michael P. Clark, Kelly M. George, Roger G. Bookland, Jack Chen, Steven K. Laughlin, Kumar D. Thakur,
Wenlin Lee, Jan R. Davis, Ed J. Cabrera, Todd A. Brugel, John C. VanRens, Matthew J. Laufersweiler,
Jennifer A. Maier, Mark P. Sabat, Adam Golebiowski, Vijay Easwaran, Mark E. Webster, Biswanath Dea and George Zhanga. Bioorganic & Medicinal Chemistry Letters 17 (2007) 1250–1253
|
| E-mail |
pywy0626@naver.com |
|
120th General Meeting of the KCS