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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-305 |
| Subject |
Synthesis of biological active N-(3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)benzenesulfonamide derivatives |
| Authors |
Ye Ji Kim, Young Dae Gong*, eunsil Lee1, Woong Lak Choi2
Department of Chemistry, Dongguk University, Korea
1Medicinal Chemistry Laboratory, Dongguk University, Korea
2Dongguk University, Korea
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| Abstract |
Vast majority of marketed drugs introduce contains hetero cyclic core skeleton. Among these heterocycles, triazolopyrimidine is a representative hetero cyclic structural motif since its derivatives have been shown diverse biological activity and pharmaceutical interests. Thus, triazolopyrimidine has been targeted to synthesize by many organic chemists and medicinal chemists and there are several reported methods to afford this core skeleton in the literature. In this context, we have tried to synthesize diverse triazolopyrimidine analogues in combinatorial way equipped with sulfonamide and aryl group at 6 and 9 positions, respectively. As a result, we’ve obtained numerous triazolopyrimidine derivatives in good yield. |
| E-mail |
kyj4660@hanmail.net |
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120th General Meeting of the KCS