120th General Meeting of the KCS

Type Poster Presentation
Area Medicinal Chemistry
Room No. Exhibition Hall 2+3
Time 10월 19일 (목요일) 11:00~12:30
Code MEDI.P-306
Subject A Highly Efficient Diversification of 1,3,4-Oxadiazole and 1,3,4-Thiadiazole analogues on Solid-phase
Authors Ji-Eun Ha, Young Dae Gong*, seung ju yang
Department of Chemistry, Dongguk University, Korea
Abstract In this work, we constructed 1,3,4-oxadiazole and 1,3,4-thiadiazole library with high level of skeletal diversity on solid-phase organic synthesis. The 1,3,4-oxadiazole and 1,3,4-thiadiazole core skeleton resin was successively afforded through desulfurative cyclization of thiosemicarbazide resin derived from a reaction between isothiocyanate resin and various hydrazides. To functionalize 1,3,4-oxadiazole and 1,3,4-thiadiazole resin, we used various alkyl halides, acid chlorides, isocyanates, isothiocyanates, aldehydes, boronic acids and amino acids. Finally, these functionalized 1,3,4-oxadiazole and 1,3,4-thiadiazole resins were treated with trifluoroacetic acid in dichloromethane, affording diverse 1,3,4-oxadiazole and 1,3,4-thiadiazole analogues in good yields and high purities.
E-mail mheun1104@hanmail.net