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Type |
Poster Presentation |
Area |
Medicinal Chemistry |
Room No. |
Exhibition Hall 2+3 |
Time |
10월 19일 (목요일) 11:00~12:30 |
Code |
MEDI.P-306 |
Subject |
A Highly Efficient Diversification of 1,3,4-Oxadiazole and 1,3,4-Thiadiazole analogues on Solid-phase |
Authors |
Ji-Eun Ha, Young Dae Gong*, seung ju yang Department of Chemistry, Dongguk University, Korea |
Abstract |
In this work, we constructed 1,3,4-oxadiazole and 1,3,4-thiadiazole library with high level of skeletal diversity on solid-phase organic synthesis. The 1,3,4-oxadiazole and 1,3,4-thiadiazole core skeleton resin was successively afforded through desulfurative cyclization of thiosemicarbazide resin derived from a reaction between isothiocyanate resin and various hydrazides. To functionalize 1,3,4-oxadiazole and 1,3,4-thiadiazole resin, we used various alkyl halides, acid chlorides, isocyanates, isothiocyanates, aldehydes, boronic acids and amino acids. Finally, these functionalized 1,3,4-oxadiazole and 1,3,4-thiadiazole resins were treated with trifluoroacetic acid in dichloromethane, affording diverse 1,3,4-oxadiazole and 1,3,4-thiadiazole analogues in good yields and high purities. |
E-mail |
mheun1104@hanmail.net |
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