120th General Meeting of the KCS

Type Poster Presentation
Area Inorganic Chemistry
Room No. Exhibition Hall 2+3
Time 10월 19일 (목요일) 11:00~12:30
Code INOR.P-50
Subject Pulse EPR Study of Cu-Aβ-Inhibitor Ternary Complex; Insight into Working Mechanism of Inhibitor on Cu-Aβ [동우화인켐㈜ 대학(원)생 선정 포스터상]
Authors Sugyeong Hong, Mi Hee Lim1, Sun Hee Kim2,*
Department of Chemistry and Nano Science, Ewha Womans University, Korea
1Department of Chemistry, Ulsan National Institute of Science and Technology, Korea
2Western Seoul Center, Korea Basic Science Institute, Korea
Abstract Alzheimer’s disease (AD) is a chronic neurodegenerative disease and AD has come to cause serious problems for both individuals and society. Interestingly, high concentration of copper ion has been found in the brain of Alzheimer’s patient; it has been proposed that copper ions affect aggregation of the amyloid beta peptide (Aβ). Recent studies on several inhibitors for Cu-Aβ aggregates suggest that the inhibitors are able to target and disassemble Cu-Aβ aggregation. Thus, clarification of the structural information of inhibitors in Cu-Aβ system is required. In this presentation, we prepared two types of small molecules as inhibitors. To illustrate the structure of ternary complexes of Cu-Aβ-inhibitor and further elucidate the inhibition mechanism, multi-technique Electron Paramagnetic Resonance (EPR) studies were conducted: 9 GHz Continuous Wave-EPR, 34 GHz pulse Electron Nuclear Double Resonance (ENDOR), and 9 GHz pulse Electron Spin Echo Envelope Modulation (ESEEM). Herein, we will present the structural information of Cu-Aβ-inhibitor ternary complexes. Our recent results may provide a designing rule of inhibitor molecules for Cu-Aβ aggregates.
E-mail hsg8926@kbsi.re.kr