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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-312 |
| Subject |
Two Photon Probes of Prostate-Specific Membrane Antigen (PSMA) for the Imaging of Colon Cancers |
| Authors |
Jung-Nyoung Heo*, tae hyeong kim1, BONG RAE CHO2
Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Korea
1Development of Drug Development and Discovery, Chungnam National University, Korea
2Department of Chemistry, Daejin University, Korea
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| Abstract |
Prostate-specific membrane antigen (PSMA) is an accessible cell-surface bound homodimeric endopeptidase, which can be efficiently targeted using urea-based derivatives of glutamic acid
such as 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA). PSMA is usually absent in normal adult tissues, exception made for normal prostate tissue and duodenum.
The tumor-targeting imaging of various PSMA ligands has been validated in rodents and in cancer patients, using nuclear medicine or molecular fluolorescence procedures. Here we will present the design of two photon probes with a PSMA binding motif, and their application for the dignosis of colon cancer in patients. |
| E-mail |
heojn@krict.re.kr |
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120th General Meeting of the KCS