120th General Meeting of the KCS

Type Symposium
Area [Inorganic Chemistry - Materials Chemistry Divisions Joint Symposium] Molecules and Materials for Safe and Sustainable Future
Room No. Room 211+212+213
Time THU 14:30-:
Code IOMT-3
Subject Designed Chemical Synthesis and Assembly of Uniform-sized Nanoparticles for Medical Applications
Authors Taeghwan Hyeon
Division of Chemical & Biological Engineering, Seoul National University, Korea
Abstract Over the last 18 years, our laboratory has focused on the designed chemical synthesis, assembly and applications of uniform-sized nanocrystals. In particular, we developed a novel generalized procedure called as the “heat-up process” for the direct synthesis of uniform-sized nanocrystals of many metals, oxides, and chalcogenides. For the last 10 years, our group has been focused on medical applications of various uniform-sized nanoparticles. Using 3 nm-sized iron oxide nanoparticles, new non-toxic MRI contrast agent was realized for high resolution MRI of blood vessels down to 0.2 mm. For the last 10 years, our group has been focused on medical applications of various uniform-sized nanoparticles. Using 3 nm-sized iron oxide nanoparticles, new non-toxic MRI contrast agent was realized for high resolution MRI of blood vessels down to 0.2 mm. Very recently, we report on the biocompatibility evaluation and MR imaging of extremely small and uniform-sized iron oxide nanoparticles in large animal models including most clinically-relevant non-human primates. These biocompatible iron oxide nanoparticles are successfully used as T1 MR contrast agent for high-resolution MR angiography of macaque monkeys. We demonstrated that intravenously administered ceria nanoparticles could substantially reduce the damage from ischemic strokes, and that triphenylphosphonium-conjugated ceria nanoparticles can localize to mitochondria and suppress neuronal death in 5XFAD transgenic Alzheimer’s disease mouse model. I will present recent advances on the fabrication of ultraflexible and stretchable electronic and optoelectronic devices integrated with various functional nanomaterials and their applications to wearable and implantable healthcare devices. We reported graphene-hybrid electrochemical devices integrated with thermo-responsive micro-needles for the sweat-based diabetes monitoring and feedback therapy. We reported the designed fabrication of multifunctional wearable electronic devices for sensing, data storage, and drug-based feedback therapy of motion-related neurological disorders such as Parkinson’s disease. We introduced electromechanical cardioplasty using an epicardial mesh made of electrically conductive and mechanically elastic silver nanowire-rubber composite material to resemble the innate cardiac tissue and confer cardiac conduction system function.
E-mail thyeon@snu.ac.kr