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| Type |
Poster Presentation |
| Area |
Analytical Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 19일 (목요일) 11:00~12:30 |
| Code |
ANAL.P-181 |
| Subject |
Quantitative analysis of residual lactide in Polylactide by NMR and GC |
| Authors |
HYERIM KIM
Samyang Biopharnaceuticals Corp., Analytical Science Center R&D Center, Korea |
| Abstract |
Polylactide(PLA) is one of the biodegradable aliphatic polyesters and has been widely applicable in the field of bio-medicine and environmentally friendly products. Industrially, PLA is produceed by ring-opening polymerization of lactide in bulk, and purified through de-volatilization at high temperature under high vaccum. The performances of PLA are directly affected by the content of residual monomer in polymers, such as having harmful effects during processing and also causing undesired property changes in the end products, lowering mechanical strength and thermal stability, and increasing the hydrolytic degradation rate of PLA products.
In this study, We have developed methods to quantitatively determine the residual lactide monomer in PLA using NMR spectroscopy compared with conventional gas chromatography(GC) methods. There was no significant difference in the results of quantification of the residual lactide monomer in PLA by NMR and GC. So, NMR spectroscopy can be a powerful tool for the analysis of residual lactide.
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| E-mail |
hyerim.kim@samyang.com |
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120th General Meeting of the KCS