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|
| Type |
Poster Presentation |
| Area |
Electrochemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 20일 (금요일) 13:00~14:30 |
| Code |
ELEC.P-459 |
| Subject |
Electrochemical detection of amyloid-β oligomers based on the signal application of nanostructured polypyrrole |
| Authors |
JIELING QIN, Mi suk Cho, Youngkwan Lee*
School of Chemical Engineering, Sungkyunkwan University, Korea
|
| Abstract |
In this work, a novel impedance sensor was developed based on a transducer of carboxyl end-capped polypyrrole nanostructure electrode and a probe of cellular prion protein (PrPc) selectively cognitive of amyloid-β oligomer. The nanostructured PPy was electrochemically synthesized by one step template-free polymerization and then, the carboxyl group was introduced by the addition of pyrrole-α-carboxylic acid, which was covalently coupled with the amine group of PrPc. The morphology of the PPy was confirmed by scanning electron microscopy. The modification and the electrochemical properties of the electrode were characterized by cyclic voltammetry and electrochemical impedance spectroscopy. The modified sensor provided to be highly sensitive to amyloid-β oligomer in a broad detection range of 0.00001-0.1 nM. The high selectivity and sensitivity of the Aβ oligomer sensor can be used in practical for the early diagnosis of Alzheimer’s disease. |
| E-mail |
galdino12@naver.com |
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120th General Meeting of the KCS