|
|
| Type |
Oral Presentation |
| Area |
Oral Presentation of Young Inorganic Chemists |
| Room No. |
Room 211+212+213 |
| Time |
THU 10:30-: |
| Code |
INOR.O-4 |
| Subject |
Inorganic nanoparticle regulates bone metabolism |
| Authors |
Shin-Woo Ha
Department of Radiology, Seoul National University Bundang Hospital, Korea |
| Abstract |
Osteoporosis is to decrease bond density caused by hormone change after menopause or aging. Bone becomes fragile and easily breaks up by minor impact. According to the statistics by Health Insurance Review & Assessment Service osteoporotic patients are largely increased because of rapid aging in the population. In 2015, total 821,754 peoples diagnosed osteoporosis, and among them 93.4% was women. There was a significant difference in gender.
Bisphosphonate derivatives, which are catabolic and prevent bone loss are used for the treatment of osteoporosis at the present. Osteonecrosis of the Jaw (ONJ) can occurs when a patient has a long treatment of the bisphosphate. Therefore, the development of an anabolic agent to promote bone mineralization is necessary. Recently we developed two types of inorganic nanoparticles; silica-based nanoparticles (NPs) and nano-hydroxyapatite (nano-HAp). We showed that silica-based NPs stimulate the differentiation of osteoblasts, bone-forming cells and mineralization, and suppress the differentiation of osteoclasts, bone-resorbing cells. In in-vivo study, young mice increase bone mineral density (BMD) and old mice inhibit to decrease BMD. The other, nano-HAp is composed of the same composition of bone, calcium and phosphates. When nano-HAp were exposed to osteoblasts, alkaline phosphatase (ALP), which modulates mineralization was strongly suppressed. Even nano-HAp didn’t internalize into the cell, but contacted on the cell surface and stimulated a cell signaling pathway. We proposed that the regulation of ALP expression resulted from DNA methylation by nano-HAp. |
| E-mail |
shinwoo.ha@gmail.com |
|
120th General Meeting of the KCS