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|
| Type |
Symposium |
| Area |
Current Trends in Organic Chemistry I: Unexpected Reactivity and Selectivity |
| Room No. |
Room 304+305+306 |
| Time |
THU 13:30-: |
| Code |
ORGN1-2 |
| Subject |
Total Synthesis of Natural Products via Nitrogen-to-Carbon Chirality Transfer |
| Authors |
Sanghee Kim
College of Pharmacy / Department of Pharmacy, Seoul National University, Korea |
| Abstract |
A chirality transfer method for the asymmetric synthesis of α-quaternary amino acid derivatives will be discussed. The high diastereoselectivity in the N-quaternization was achieved via the control of stereodynamics of proline. The generated N-chirality of quaternary ammonium was transferred back to the α-carbon chirality via stereospecific reactions (N→C chirality transfer) to give α-quaternary prolines. This new strategy was applied in a straightforward manner to the total synthesis of alkaloid natural products. |
| E-mail |
pennkim@snu.ac.kr |
120th General Meeting of the KCS