120th General Meeting of the KCS

Type Poster Presentation
Area Environmental Energy
Room No. Exhibition Hall 2+3
Time 10월 19일 (목요일) 11:00~12:30
Code ENVR.P-517
Subject Influence of exposure to perfluoroalkyl substances (PFASs) on the Korean general population: 10-year trend and health effects
Authors Yu-Gyeong Kang, YOON-SEOK CHANG *
Division of Environmental Science and Engineering, Pohang University of Science and Technology, Korea
Abstract This study demonstrated the 10-year trend of 13 perfluoroalkyl substances (PFASs) in serum samples of 786 adults living in Seoul, Korea. PFAS levels began to gradually increase in 2006 and then decreased starting in 2013. We found that PFAS levels were higher in males than in females and exhibited positive correlations with age. Whereas PFASs were not significantly correlated with body mass index, we observed positive correlations with total cholesterol, low-density lipoprotein cholesterol, and triglyceride and negative correlations with high-density lipoprotein cholesterol. In particular, uric acid and free thyroxine (fT4) showed positive correlations with major congeners. Inconsistent correlations were confirmed between thyroid stimulating hormone and PFASs. We demonstrated significant correlations with fT4 and perfluorononanoic acid (PFNA), perfluorohexane sulfonate (PFHxS), and perfluorodecanoic acid (PFDA). PFHxS and perfluorododecanoic acid (PFDoDA) levels showed significant differences between participants with and without diabetes. In addition, principal component analysis suggested that there might be differences in disease manifestation based on the congener distribution of PFASs. This was the longest and largest scale study to date, as well as the first on the temporal trends of 13 PFAS congeners in serum samples obtained from the Korean general population.
E-mail ygkang74@postech.ac.kr