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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-337 |
| Subject |
Design and Synthesis of Novel DYRK1B Inhibitors |
| Authors |
EunJi Heo, Sung-Youn Chang1, Hyuk Lee1,*
Development of Drug Development and Discovery, Chungnam National University, Korea
1Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Korea
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| Abstract |
Dual-specificity tyrosine-phosphorylation-regulated kinase (DYRK1B) has been known to play a key role for maintaining cells in quiescence, and its Amplification in various tumor types has been observed such as ovarian cancer, colon cancer, panceratic cancer, and lung cancer, when compared to normal tissue [1]. Hence, many studies and development of DYRK1B inhibitors are actively in progress. We designed and synthesized novel DYRK1B inhibitors having potent enzymatic activities. Our data suggest therapeutic potential of DYRK1B inhibitors for the treatment of cancers.
[1] Bioorganic & Medicinal chemistry 2015, 23, 4434-4441
J. Med. Chem. 2015, 58, 2834-2844 |
| E-mail |
heoeunjiii@naver.com |
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120th General Meeting of the KCS