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|
| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 19일 (목요일) 11:00~12:30 |
| Code |
BIO.P-262 |
| Subject |
Th role of NUDT9 in hypoxia-inducible factor pahtway |
| Authors |
byungboon Yoon, So Yeon Kim1,*
Center for Theragnosis, KIST, Korea
1Center for Theragnosis, Korea Institute of Science and Technology, Korea
|
| Abstract |
Although numerous kinases have been reported to regulate HIF-1α stability and activity, few phosphatases are known to be involved in HIF-1α regulation. In this study, we report that ADP-ribose (ADPR) pyrophosphatase, nudix hydrolase 9 (NUDT9) negatively regulates HIF-1α accumulation by modulating AMP-activated protein kinase (AMPK) signaling pathway. Knockdown of NUDT9 activates transient receptor potential cation channel subfamily M Member 2 (TRPM2), resulting in Ca2+ influx mediated activation of calcium/calmodulin-dependent protein kinase kinase (CAMKKβ). AMPK activation by CAMKKβ is shown to enhance HIF-1α accumulation and the possible downstream effector for AMPK is identified. Our finding provides insights into the roles of NUDT9 phosphatase as additional, discrete modulator of hypoxia stimulated HIF-1α accumulation through different signaling pathways. |
| E-mail |
023583@kist.re.kr |
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120th General Meeting of the KCS