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| Type |
Poster Presentation |
| Area |
Polymer Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 20일 (금요일) 13:00~14:30 |
| Code |
POLY.P-35 |
| Subject |
Solubilization of wrinkle-improving functional materials using nanoparticles |
| Authors |
youngwoo lee*, Jooyoung Ahn1, Seok Hee Kang2
Development of Drug Development and Discovery, Chungnam National University, Korea
1Department of Pharmacy, Korea University Sejong Campus, Korea
2Korea Research Institute of Chemical Technology/ M, University of Science & Technology, Korea
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| Abstract |
Oleanolic acid, which is used as a major ingredient of medicine and cosmetics separated from various plant species, is an effective ingredient of natural plant and has excellent efficacy against anti-inflammation and stimulation related to skin's physiological activity. in addition, as an anti-aging function, it promotes the synthesis of procollagens, ceramides, filaggins, those which are important for collagen production, and it also has the function of inhibiting the activity of MMP-1, which is an enzyme that destroys polymeric proteins such as collagen. It features a dual anti-aging system that promotes collagen production and prevents destruction. Although Oleanolic acid has a anti-wrinkle function, the low solubility in aqueous solution makes it difficult to be applied as an functional cosmetic material.
In this study, the biocompatible polymer is used to solubilize oleanolic acid to remedy the poor solubility. The permeation study was processed for 24 hours using Franz cell to confirm skin permeation rate, and the particle size was analysed by ELS-Z particle analyser. Samples were kept in 40℃ for 3 months to confirm long term stability of the nanoparticle.
As a result of this study, the solubility of oleanolic acid was improved as it was encapsuled with biocompatible polymers. The skin permeation rate of produced nanoparticle was 15% while rate of control group was 9%. The nanoparticle size was suitable ranging 20-150nm. Nanoparticle was uniform in size and there was no precipitation occurred during long term stability test. This results show that oleanolic acid nanoparticle is expected to be greatly useful in functional cosmetic as an anti-wrinkle material.
본 연구는 미래창조과학부 2017 기술이전사업화 과제의 지원을 받아 수행되었으며 이에 감사드립니다.
(과제번호 : 2017-01-DD-049)
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| E-mail |
youngwoo9211@naver.com |
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120th General Meeting of the KCS