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|
| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 19일 (목요일) 11:00~12:30 |
| Code |
BIO.P-265 |
| Subject |
Glycan-density dependent binding of pathogenic proteins and cells |
| Authors |
Hyoung sub Kim, Injae Shin*
Department of Chemistry, Yonsei University, Korea
|
| Abstract |
Pathogens express various glycan-binding proteins (adhesins or lectins) for infection of humans. For example, Helicobacter pylori strains express SabA and BabA proteins on their surface to bind sialyl Lewis x and Lewis b on epithelial cells for infection. Another important pathogenic lectin is Hemagglutinin expressed on influenza virus. This viral lectin recognizes NeuNAc2,3Gal or NeuNAc2,6Gal on epithelial cells. Thus, understanding of pathogenic protein-glycan interactions is of great importance to discover diagnostic and/or therapeutic agents. To rapidly analyze interactions between pathogenic proteins and glycans, we have developed carbohydrate microarrays containing a number of glycans in a density-dependent manner. By using the microarrays, we have analyzed pathogenic protein-glycan interactions. It was found that pathogenic proteins recognize multivalent glycans on the surface more tightly compared to monovalent glycans. We also made an attempt to detect intact pathogens using glycan microarrays. |
| E-mail |
jkk57107@naver.com |
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120th General Meeting of the KCS