120th General Meeting of the KCS

Type Poster Presentation
Area Polymer Chemistry
Room No. Exhibition Hall 2+3
Time 10월 20일 (금요일) 13:00~14:30
Code POLY.P-36
Subject Development of Natural antimicrobial materials encapsulated nanoparticles
Authors Jooyoung Ahn, Soon Hong Yuk*, youngwoo lee1
Department of Pharmacy, Korea University Sejong Campus, Korea
1Development of Drug Development and Discovery, Chungnam National University, Korea
Abstract Among the natural substances, mastic, rosin, myrrh and propolis are famous for their antibacterial effect, but they are substances which are not applicable to various products due to low solubility in aqueous solution. In this study, we have developed a material that can be applied to various products by solubilizing those insoluble antimicrobial material as polymer micellar nanoparticles using biocompatible solvents and block copolymer . Nanoparticles based on surfactants are nano-sized particles formed by amphiphilic (hydrophilic / hydrophobic) polymers in aqueous solution. Amphiphilic block copolymers are grouped in an aqueous solution to form hydrophobic regions inside and outside hydrophilic regions. The nanoparticles were prepared by encapsulating a hydrophobic material such as a mastic and rosin inside the micelle. The particle size of the prepared nanoparticles was analyzed using a particle size analyzer (ELS-Z). To confirm stability of nanoparticles, they were stored at 40 ° C and 25 ° C for more than 3 months respectively. The antibacterial effect was confirmed by microbial detection test for aerobic bacteria and fungi. Mastic, and rosin nanoparticles were found to have an optimal size of 100 nm or less, and the nanoparticles did not show large particle changes or precipitation. Antibacterial effect was confirmed by showing that less than 10 CFU / ml of aerobic bacteria and fungi were detected. We are expecting that the nanoparticle made of natural antimicrobial material can be very useful as environmentally friendly antimicrobial agents using natural materials in the future. 본 연구는 한국산업기술 진흥원 R&D 재발견 사업의 지원을 받아 수행되었습니다 (과제번호:N0002204)
E-mail maevis@krict.re.kr