120th General Meeting of the KCS

Type Poster Presentation
Area Life Chemistry
Room No. Exhibition Hall 2+3
Time 10월 19일 (목요일) 11:00~12:30
Code BIO.P-271
Subject The genetic association with three endocytosis-related genes and Alzheimer’s disease
Authors WON-CHEOUL JANG *, Sang-Hyune Kim, Jin-ho KIM, minseon Kim, seunghun jeon, Youngkwan Kim, donghyeon Yeo, mingyo Kang, Dayeon Lee1, yerim Lee
Department of Chemistry, Dankook University, Korea
1Department of Molecular Biology, Dankook University, Korea
Abstract Alzheimer’s disease (AD) is the most common type of dementia among the people more than 65 years-old. Many reports have been performed to investigate the pathogenesis of AD. Recently, several reports showed that defects in endocytic membrane trafficking and vesicular transport were associated with AD. The endocytosis was essential for releasing neurotransmitters, as increasing membrane retrieval and neuronal growth factor receptors. For these reasons, we examined the association between endocytosis-related gene polymorphisms and risk of AD with 144 cases and 335 controls. We evaluated the association between three polymorphisms and AD using meta-analysis. Our results showed the significant association between endocytosis-related gene polymorphisms and risk of AD. Especially, the PICALM rs3851179 polymorphism was detected decreasing risk for AD. It may be a protective genetic factor to progression of AD. However, the other polymorphisms indicated increasing risk factor to AD. In conclusion, the three endocytosis-related gene polymorphisms are potential risk factor with pathogenesis of AD.
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