120th General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Analytical Chemists I
Room No. Room C311+C312
Time THU 09:00-:
Code ANAL1.O-1
Subject Application of Powder X-ray Diffraction Technique to Structural Analysis of Self-assembled Structures Consisting of Peptide Foldamers
Authors Jintaek Gong, Hee-Seung Lee1,*
Natural Science Research Institute, Korea Advanced Institute of Science and Technology, Korea
1Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea
Abstract A well-designed beta-peptide foldamer can self-assemble to create various well-defined 3D architectures in aqueous solutions. The term foldecture is combination of the words foldamer and architecture. Our group has reported several unprecedented shapes of foldectures, such as a windmill and a molar tooth. These were highly homogenous both in terms of their size and morphology. Furthermore, to explore their potential use as functional materials, we recently published a study in which a carboxyl group was exposed to specific rhombic facets of foldectures. We found new potential capabilities of foldecture in relation to their mechanical properties, such as an anisotropic shape of a micro-sized container through the creation of a hollow cavity inside the container. Meanwhile, research on the functionalization of foldectures is expanding, as comprehending the self-assembly process and the resulting 3D shapes requires additional work. Hence, the structural determination of the molecular packing structure of foldecture is essential. In relation to this, the powder X-ray diffraction technique has been utilized here due to the dimensions and kinetical experimental conditions of foldecture. A PXRD analysis with synchrotron radiation was adequate to determine the packing structure with well-organized bonds and angle restraints. Further, it was able to designate the absolute orientation of the foldamers involved based on the predicted preferred orientation approximation. The use of a PXRD analysis on foldecture aided the understanding of the shape and properties of the newly formed foldecture and can be expected to play a major role in designing original examples of foldecture in the future.
E-mail kalimeriashd@kaist.ac.kr