120th General Meeting of the KCS

Type Poster Presentation
Area Electrochemistry
Room No. Exhibition Hall 2+3
Time 10월 20일 (금요일) 13:00~14:30
Code ELEC.P-497
Subject Continuous glucose monitoring sensors modified by nitric oxide-releasing nanofiber for improving biocompatibility: Lifetime in freely-moving rat model with a wireless system
Authors Min Heo, Yeong Rim Kim, Hee June Jeong, Doyeon Lee1, Gi-Ja Lee1, Jae Ho Shin2,*
Medical Sensor·Biomaterial Research Institute, Kwangwoon University, Korea
1Department of Biomedical Engineering, Kyung Hee University, Korea
2Medical Sensor·Biomaterial Research Institute/ Department of Chemistry, Kwangwoon University, Korea
Abstract Continuous glucose monitoring provides maximal information about shifting blood glucose levels throughout the day and facilitates the decision-making for optimal treatment of the diabetic patients. Designing in vivo glucose biosensor for clinical use, however, remains a significant challenge due to poor biocompatibility. Indeed, surface fouling affects the long-term utility of such devices by reducing glucose diffusion to the sensor and increasing the risk of infection. To remove or reduce such surface biofouling, a number of strategies have been explored including modifying the outer surfaces of biosensors with a range of polymeric membranes that resist protein adhesion. Unfortunately, these strategies have not dramatically improved the long-term performance of in vivo sensors. With the discovery of nitric oxide (NO) as a potent antithrombotic agent, the study of NO has been extended to the field of biomaterials. Due to its short half-life (i.e., <10 s) in biological milieu, NO represents an attractive species for improving the biocompatibility of indwelled medical devices. Herein we demonstrate an implantable glucose microsensor modified with NO-releasing silica/polymer hybrid nanofibers. To control NO release properties (e.g., total NO release amount, half-life time, and maximum flux) of fibers, various parameters (e.g., type/amount of NO donors and fiber diameter) are tuned. In addition, the in vivo sensor performance (using a freely-moving rat model equipped with a wireless signal transmitter/receiver device) is evaluated, in terms of sensor lifetime, accuracy, and stability.
E-mail uncompress@kw.ac.kr