120th General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Analytical Chemists I
Room No. Room C311+C312
Time THU 09:22-:
Code ANAL1.O-4
Subject Analysis of Correlation between Structure of Linear Surfactants and Acute Eye Irritation Scores
Authors Sujin Cho, Tian Tian, Seog Woo Rhee*
Department of Chemistry, Kongju National University, Korea
Abstract In this work, we determined the eye irritation scores of surfactants with linear alkyl chains by HET-CAM assay using hen’s eggs and investigated the correlation between the structure of surfactants and eye irritation scores. Surfactants with a cationic (ammonium salt), neutral, anionic (sulfate) head groups and a linear alkyl chain with 8 to 16 carbons as the tail group were selected. The properties of surfactant forming micelles in aqueous solution were measured by an electrical conductivity method and an absorbance measurement method. The eye irritation scores of surfactants at various concentrations were measured by the HET-CAM assay using hen’s eggs as an alternative animal test. Based on the experimental results, we found a significant correlation between the structural properties of the surfactant and the critical micelle concentration, and the acute irritation score of the surfactant. The results of this study will be used to develop cell-based devices using microfluidic chips that can replace the HET-CAM assay.
E-mail jisanrhee@kongju.ac.kr