120th General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Analytical Chemists I
Room No. Room C311+C312
Time THU 09:24-:
Code ANAL1.O-5
Subject Assessment of Phototoxicity Inhibition of Flavone-based Materials
Authors Sung Eun Lee, Tian Tian, Seog Woo Rhee*
Department of Chemistry, Kongju National University, Korea
Abstract In this work, we investigated the phototoxicity inhibition process of flavone-based materials using the 3T3 NRU assay, an in vivo acute phototoxicity evaluation method. Amiodarone HCl and chlorpromazine HCl were used as phototoxic materials, and chrysin and apigenin were used as photoinhibition inhibitors. The phototoxicity index, PIF value and MPE value, were calculated based on the cell viability measured as a function of concentration. When cells were treated with solutions containing both chlorpromazine and flavone-based materials, both chrysin and apigenin reduced the phototoxicity of chlorpromazine by UVA. In addition, we will discuss the cytotoxic and phototoxic mechanisms of each material and the phototoxicity inhibition process of flavone-based materials.
E-mail jisanrhee@kongju.ac.kr