120th General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Analytical Chemists I
Room No. Room C311+C312
Time THU 10:41-:
Code ANAL1.O-41
Subject Synthesis of Silicon-Coated Gold Nanoparticle for Dual Imaging and Therapy
Authors Soomin Hwang, Hyeonglim Seo, Hoeil Chung1, Seunghyun Lee2, Youngbok Lee*
Department of Bio-Nano Technology, Hanyang University, Korea
1Department of Chemistry, Hanyang University, Korea
2Department of Advanced Materials Engineering, The University of Suwon, Korea
Abstract Gold nanoparticles (Au NPs) have been used as effective Surface-Enhanced Raman Spectroscopy (SERS) substrates for decades. We synthesized the Au NPs through seeded growth method using a sodium citrate as stabilizer and reducing agent. However, this citrate-stabilized Au NPs become unstable when the environment changes abruptly, and agglomeration and sedimentation usually occur because of the properties of the stabilizers on the Au NPs surface. Therefore, improving the stability of Au NPs has important significance. At present, there are many coating methods to stabilize the Au NPs, such as silver, alumina and so on. However, one such robust functionalization that has been proven to enhance gold nanoparticle stability both thermodynamically and chemically is silica coating. The synthesis of Au NPs and silica coating were confirmed by by UV spectroscopy, SEM, and TEM. In addition, we converted m-SiO2 to mesoporous silicon (m-Si) by using magnesiothermic reduction. Si can make an amplified signal by DNP, one of the hyperpolarization phenomena, so that it can be used for MR imaging probe. Consequently, silicon-coated gold nanoparticle (Au NPs@Si) can be used for dual imaging, SERS and MR imaging. Moreover, Au NPs have been used for thermal therapy for cancer as photo-thermal agents for a long time and mesoporous silicon can used for drug delivery. Therefore, Au NPs@Si can be used for dual therapy, both thermotherapy through the Au NPs and chemotherapy through mesoporous silicon. As a result, we developed Au NPs@Si as the probe for dual therapy and dual imaging for cancer diagnosis and therapy.
E-mail soogtnals@naver.com