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| Type |
Oral Presentation |
| Area |
Oral Presentation of Young Analytical Chemists I |
| Room No. |
Room C311+C312 |
| Time |
THU 10:43-: |
| Code |
ANAL1.O-42 |
| Subject |
Synthesis of Porous Silicon and Carbon Nano-spheres as Hyperpolarized MRI Probes for Cancer Diagnosis |
| Authors |
DOKYUNG KIM, Ikjang Choi, Youngbok Lee*
Department of Bionano Technology, Department of , Korea
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| Abstract |
Silicon and carbon based nano-spheres have been attracting a lot of interest in the field of biomedical applications due to their biocompatibility and biodegradability in vivo, as well as their flexible surface modifications. Here, we synthesized and investigated porous silicon (PSi NPs) and carbon nano-spheres (CNS) as hyperpolarized MR imaging probes. The Si NPs and CNS have many great benefits to the hyperpolarized MR imaging. Since core regions of the crystalline nano-spheres are mostly protected from a main relaxation source, such as paramagnetic centers existing at surface defect sites, these nano-spheres show extremely long depolarization times (usually longer than 30 mins), resulting in high MR image contrast with minimum or no background signals. In addition, paramagnetic centers on the surface defect sites play a pivotal role in generating MR signal enhancements induced by dynamic nuclear polarization (DNP) processes, thereby not necessary to add external radical sources. Two different synthetic approaches were demonstrated in order to produce PSi NPs and CNS. (1) Magnesiothermic reduction of porous silica (synthesized by modified stöber method with CTAB template) was processed in order to yield PSi NPs. (2) CNS was synthesized through the polymerization process of dopamine. Several spectroscopic and microscopic results suggest that the synthesized PSi NPs and CNS can potentially be utilized as biocompatible and targetable contrast agents for hyperpolarized MRI researches. |
| E-mail |
dokyung_13@naver.com |
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120th General Meeting of the KCS