120th General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Analytical Chemists II
Room No. Room C308+C309
Time FRI 10:31-:
Code ANAL2.O-36
Subject Developed to Overhauser Dynamic Nuclear Polarization Nuclear Magnetic Resonance Systems for Signal Enhancement
Authors JiWon Kim, Seung-Bo Saun1, Oc Hee Han1,*
Department of Chemistry and Nano Science, Ewha Womans University, Korea
1Western Seoul Center, Korea Basic Science Institute, Korea
Abstract Nuclear magnetic resonance (NMR) spectroscopy has advantages such as non-destructive observation of molecular structure and dynamics, analysis of amorphous samples, and high selectivity of nuclear species to be observed. However, NMR has the disadvantage of low sensitivity because it uses low energy. In order to overcome the disadvantage of NMR, overhauser dynamic nuclear polarization (ODNP) NMR system which amplifies NMR signals from several tens to several hundred times using the interaction of electron spins and nuclear spins within about 1 nm from the electron spin centers. Therefore, a local region can be designated by selectively positioning the spin markers in the sample. ODNP NMR can be used to measure the diffusion rate of water in a variety of materials and to measure the dependence of binding between protein and water on solvents. In our laboratory, an Electron Paramagnetic Resonance (EPR) spectrometer and NMR components (radio frequency pulse modules, NMR tuning boxes, ODNP NMR probes, etc.) has been assembled together and instrumental optimization for the best amplification is currently in progress.
E-mail jwkim27@kbsi.re.kr