121st General Meeting of the KCS

Type Poster Presentation
Area Organic Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code ORGN.P-315
Subject One-Pot Synthesis of Indolizines via Sequential Rhodium-Catalyzed [2 + 1]-Cyclopropanation, Palladium-Catalyzed Ring Expansion, and Oxidation Reactions from Pyridotriazoles and 1,3-Dienes
Authors Kyusik Um, Younghyeon Baek, Phil Ho Lee*
Department of Chemistry, Kangwon National University, Korea
Abstract

Development of synthetic methods for accessing a variety of functionalized N-heterocyclic compounds is a significant objective in the fields of organic and medicinal chemistry. Because indolizine derivatives containing nitrogens at their ring junction have been found in a number of natural products, pharmaceuticals, and bioactive compounds, the development of expeditious approaches for the construction and functionalization of indolizine derivatives has gained much attention. However, 3-(alkenyl)indolizine derivatives, a vital skeleton for building phosphoinositide 3-kinase inhibitors, have rarely been reported. For this reason, we developed a one-pot synthetic route to 3-(alkenyl)indolizine derivatives via sequential Rh-catalyzed [2 + 1]-cyclopropanation, Pd-catalyzed ring expansion, and oxidation reactions from pyridotriazoles and 1,3-dienes. This work was supported by the Human Resource Training Program for Regional Innovation and Creativity through the Ministry of Education and National Research Foundation of Korea (NRF-2015H1C1A1035955).

E-mail kyusik55@naver.com