A convenient and environmentally friendly procedure for the synthesis of 2-amino-5-oxo-4-phenyl-4H,5H-pyrano[3,2-c]chromene-3-carboxamide via a one-pot, three-component condensation of 4-hydroxycoumarin, aldehydes and cyanoacetamide in the presence of catalytic amount of p-toluenesulfonic acid (p-TSA) as a highly active acid catalyst in EtOH conditions at 80 °C. This new procedure offers several advantages such as shorter reaction times, excellent yields, operational simplicity, a wide range of functional group tolerance, simple and easy experimental work-up procedure. |