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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-575 |
| Subject |
Synthesis, characterization, and biological evaluation of ionic liquids for BNCT |
| Authors |
SAEM I PARK, SE YOUNG PARK, SO-YOUNG MA1, JONG DAE LEE*
Department of Chemistry, Chosun University, Korea
1Photovoltaic Materials, Korea University Sejong Campus, Korea
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| Abstract |
New synthetic methods to prepare imidazolium and dimethylaminopyridium having alkyl (C4, C5, C6) substituents containing the boron anion such as tetrafluoroborate (BF4–) , bis(oxalato)borate (BOB–), bis(malonato)borate (BMLB–) and dicarbollide (C2B9H12–) have been developed. The 1-alkyl-3-methylimidazolium tetrafluoroborate is liquid phase at room temperature, however another imidazolium salts show that cohesion increase at lower temperature A series of experiments have been conducted using relevant assays to estimate the cytotoxicity of selected imidazolium and dimethylaminopyridium based on the ionic liquids. The [CnMIM][BF4]salt was less cytotoxicity than another boron anions. The cytotoxicity of 1-alkyl-3-methylimidazolium salts show high cytotoxicity with increasing alkyl chain length of the cation. However, the 1-alkyl dimethylaminopyridium salts show high cytotoxicity, due to their bulk sizes. |
| E-mail |
saemi0323@naver.com |
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121st General Meeting of the KCS