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|
| Type |
Oral Presentation |
| Area |
Oral Presentation in Chemistry of Life |
| Room No. |
Room 203 |
| Time |
THU 09:00-: |
| Code |
BIO.O-1 |
| Subject |
Development and Bioactivity Evaluation of New Anticonvulsants
|
| Authors |
songmi Bae, Ju Hyun Song, Dai Il Jung*, JUNGTAI HAHN1
Department of Chemistry, Dong-A University, Korea
1Department of Beauty Care, U1 University, Korea
|
| Abstract |
The human brain is the source of human epilepsy. Epilepsy is a chronic disorder, the hallmark of which is recurrent, unprovoked seizures. The seizures in epilepsy may be related to a brain injury or a family tendency, but often the cause is completely unknown. The exact mechanism of epilepsy is unknown, but a little is known about its cellular and network mechanisms. In connection with the development of new anticonvulsant, we examined the structural similarities of various anticonvulsants, known to act by different mechanisms. So we designed the active structure such as ester or acid anhydride in a single molecule as new anticonvulsant of broader spectrum. Herein we wish to report the synthesis of a series of valproic acid and their in vivo and in vitro anticonvulsant evaluations. |
| E-mail |
deliveryme@naver.com |
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121st General Meeting of the KCS