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|
| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-330 |
| Subject |
Pd-Catalyzed Oxidative Alkenylation/Annulation of N-Ts-Benzamides with Styrenes: Synthesis of (E)-3-Arylmethyleneisoindolin-1-ones |
| Authors |
TaeYun Ko, So Won Youn*
Department of Chemistry, Hanyang University, Korea
|
| Abstract |
Due to their various biological properties and wide application in pharmaceutical research, isoindolinones are one of the most important heterocycle compounds. Especially, 3-arylmethyleneisoindolin-1-ones have been utilized for the synthesis of numerous natural products and pharmacologically important compounds. Among the various synthetic strategies, the majority of synthetic routes relies on the use of acrylates and benzamides. Even if various methods for the synthesis of isoindolinone derivatives have been reported for decades, more efficient synthetic methods using styrenes are still in great demand. Recently, our group developed a highly efficient one-pot synthesis of (E)-3-arylmethyleneisoindolin-1-ones from N-Ts-benzamides and styrenes under Pd catalysis, forming new C-C and C-N bonds with high efficiency and stereoselectivity. |
| E-mail |
ktohouse25@naver.com |
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121st General Meeting of the KCS