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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-333 |
| Subject |
Facile synthesis of guanidine containing antihistamine conjugates |
| Authors |
Ju Mi Lee, Jeong Tae Lee*
Department of Chemistry and Institute of Applied Chemistry, Hallym University, Korea
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| Abstract |
The guanidine derivative (9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a] azepin-3-amine hydrochloride) (1) is a selective H1 receptor antagonist and mast cell stabilizer with minimal side effects. It is mainly used in eye drops to treat allergic conjunctivitis. It also prevents the release of proinflammatory chemical mediators from the blood vessel to halt progression of the allergic response. In order to improve its analgesic effect, herein, we report the synthesis of novel conjugates generated by coupling of 1 with nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and salicylic acid. Furthermore, synthesis of other conjugates containing γ-aminobutyric acid (GABA) (neurotransmitter) and gabapentin (anticonvulsant agent) moieties are also in progress. |
| E-mail |
wnal0669@naver.com |
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121st General Meeting of the KCS