121st General Meeting of the KCS

Type Poster Presentation
Area Physical Chemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code PHYS.P-79
Subject Ultrasmall Gadolinium Oxides Nanoparticles as Multifunctional Agent: MRI, Tumor Detection and Gadolinium Neutron Capture Therapy
Authors Son-Long Ho, Gang Ho Lee*
Department of Chemistry, Kyungpook National University, Korea
Abstract Magnetic resonance imaging (MRI) is widely used as noninvasively diagnostic tool because MRI has high spatial resolution and high sensitivity. Besides, MRI could combine with a therapeutic agent, in which one compound is able for both diagnosis and therapy of diseases. From that perspective, gadolinium nanoparticles have great potential to work as theragnostic agents. First of all, gadolinium ion (Gd(III)) has seven unpaired 4f (8S7/2)electrons , which give large electron magnetic moment, and besides, Gd(III) also induce efficiently the longitudinal relaxation of water protons, making Gd(III) ion the most suitable T1 MRI contrast agent. Another point should be taken into consideration is that gadolinium has high thermal neutron capture cross-section, for example 157Gd isotope has s value of 254000 barnes, that is 60 times larger than the value of 10B, a commonly used agent for boron neutron capture therapy (BNCT). Therefore, gadolinium nanoparticles are promising candidates for neutron capture therapy of tumors. Herein, poly(acrylic acid)-rhodamine coated gadolinium oxide nanoparticles were synthesized and used as MRI, tumor detection agent and in vitro gadolinium neutron capture therapy agent (GdNCT) of human glioblastoma astrocytoma (U87MG) cells.
E-mail sonlongh@gmail.com