121st General Meeting of the KCS

Type Poster Presentation
Area Medicinal Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code MEDI.P-576
Subject The surface water accessibility-dependent relaxivity tuning of Eu-doped iron oxide nanoparticles and the monitoring of protein interaction
Authors Jeong Chan Park
Pohang University of Science and Technology, Korea
Abstract Herein, we report the relaxivity tuning of T1-T2 dual-modal MRI contrast agents (CAs) depending on the surface water accessibility, and the monitoring protein interactions with T1-T2 dual-modal MRI CAs. Europium-doped iron oxide (EuIO) as core nanoparticles (NPs) is prepared by a thermal decomposition method. Citrate (Cit), alendronate (Ale) and PMAO/PEG (PP) as surface materials, having different hydrophobicity, are employed for the surface water accessibility-dependent relaxivity tuning of the NPs, resulting in EuIO-Cit, EuIO-Ale and EuIO-PP, respectively. Correlation between the hydrophobicity of surface materials and the longitudinal relaxivity (r1) of T1-T2 dual-modal MRI CAs presents exponential decay feature. The r1 relaxivity of EuIO-Cit exhibits 13.2 fold higher than that of EuIO-PP. According to the surface materials, EuIO can act as T1-T2 dual-modal (EuIO-Cit) or T2-dominanted MRI CAs (EuIO-PP). In addition, it is explored that the feasibility of the resulting nanosystem as a sensor to report environmental changes, such as albumin interaction. The albumin interaction on T1-T2 dual-modal MRI CAs shows the change in both T1 and T2 relaxation time, which would the mutually confirmative information. The surface water accessibility-dependent relaxivity tuning approach may provide insightful strategy for bio-applications of T1-T2 dual-modal MRI CAs and give a fresh impetus for the development of the novel stimuli-responsive T1-T2 dual-modal MRI nanoplatforms for various biomedical applications.
E-mail goodnews1979@gmail.com