|
Type |
Poster Presentation |
Area |
Medicinal Chemistry |
Room No. |
Event Hall |
Time |
4월 19일 (목요일) 11:00~12:30 |
Code |
MEDI.P-576 |
Subject |
The surface water accessibility-dependent relaxivity tuning of Eu-doped iron oxide nanoparticles and the monitoring of protein interaction |
Authors |
Jeong Chan Park Pohang University of Science and Technology, Korea |
Abstract |
Herein, we report the relaxivity tuning of T1-T2 dual-modal MRI contrast agents (CAs) depending on the surface water accessibility, and the monitoring protein interactions with T1-T2 dual-modal MRI CAs. Europium-doped iron oxide (EuIO) as core nanoparticles (NPs) is prepared by a thermal decomposition method. Citrate (Cit), alendronate (Ale) and PMAO/PEG (PP) as surface materials, having different hydrophobicity, are employed for the surface water accessibility-dependent relaxivity tuning of the NPs, resulting in EuIO-Cit, EuIO-Ale and EuIO-PP, respectively. Correlation between the hydrophobicity of surface materials and the longitudinal relaxivity (r1) of T1-T2 dual-modal MRI CAs presents exponential decay feature. The r1 relaxivity of EuIO-Cit exhibits 13.2 fold higher than that of EuIO-PP. According to the surface materials, EuIO can act as T1-T2 dual-modal (EuIO-Cit) or T2-dominanted MRI CAs (EuIO-PP). In addition, it is explored that the feasibility of the resulting nanosystem as a sensor to report environmental changes, such as albumin interaction. The albumin interaction on T1-T2 dual-modal MRI CAs shows the change in both T1 and T2 relaxation time, which would the mutually confirmative information. The surface water accessibility-dependent relaxivity tuning approach may provide insightful strategy for bio-applications of T1-T2 dual-modal MRI CAs and give a fresh impetus for the development of the novel stimuli-responsive T1-T2 dual-modal MRI nanoplatforms for various biomedical applications. |
E-mail |
goodnews1979@gmail.com |
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