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|
| Type |
Oral Presentation |
| Area |
Oral Presentation of Young Material Chemists |
| Room No. |
Samda Hall A |
| Time |
THU 09:44-: |
| Code |
MAT.O-5 |
| Subject |
89Zr labeled biomimetic nanoparticles for PET imaging |
| Authors |
Jun Young Lee, JEONG HOON PARK*
Radiation Instrumentation Division, Korea Atomic Energy Research Institute, Korea
|
| Abstract |
Immune control proteins camouflaged nanoparticles have recently been studied for their biological compatibility, long-term circulation, retention of cell membrane properties, low toxicity and ability to avoid immune-barrier. In this study, we have successfully synthesized and evaluated red blood cell membrane (Rm)-camouflaged, hollow mesoporous silica nanospheres (HMSNs). Rm-HMSNs effectively accumulate in the tumor by prolonged blood circulation cause by avoiding phagocytosis of macrophage. Its distribution in the body over a long period of time was confirmed with positron emission radionuclide 89Zr having long half-life of 3.3 days. Especially, as it is a radiopharmaceutical, NPs can be coated with a low volume of animal blood. The extraction and use of Rm from the same animal helped to overcome the immune barrier. This strategy can be applied extensively to identify the long-term in vivo behavior of nano-drugs while enhancing their biocompatibility. |
| E-mail |
somasky@naver.com |
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121st General Meeting of the KCS