121st General Meeting of the KCS

Type Poster Presentation
Area Organic Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code ORGN.P-343
Subject Synthesis of Spiro[imidazolidine-4,11'-indeno[1,2-b]quinoxalin-hydantoins and Imidazolidine-2,4-diones
Authors LEE SEUNG RYUL, Dai Il Jung*, JUNGTAI HAHN1, Eon Jin Lee
Department of Chemistry, Dong-A University, Korea
1Department of Beauty Care, U1 University, Korea
Abstract In pharmaceuticals, hydantoin derivatives form a class of anticonvulsants phenytoin and fosphenytoin both contain hydantoin moieties and are both used as anticonvulsants in the treatment of seizure disorders. Also Indenoquinoxaline derivatives in organic synthesis are an important class of nitrogen-containing heterocycles and are useful building blocks found in a wide range of biologically active compounds. Moreover, carbonyl group of indeno[1,2-b]quinoxalin-11-ones can further be modified to pharmacologically important functional groups such as hydantoin ring or Schiff base. Hydantoin is found in medically important compounds such as the anticonvulsants, phenytoin and fosphenytoin, which are used to treat seizure disorders. Schiff bases have been reported to possess a wide range of medicinal and pharmacological activities such as anticonvulsants, anti-inflammatory agents, analgesics and antimicrobial agents. In this study, a series of indeno[1,2-b]quinoxalin-11-one derivatives are synthesized by the condensation between ninhydrin and various aromatic diamines. A reasonable sequence of events is the addition to carbonyl, substitution of hydroxyl and two elimination of water. Resulting indeno[1,2-b]quinoxalin-11-one derivatives were further reacted to form hydantoins and Schiff base moieties. we tried Synthesis of indenoquinoxalines from ninhydrin and diamines. Spirohydantoins anticipated anticonvuksant activity from the reactions od 2-benzoylpyridine, 2-benzoylthiophen, and indenoquinoxalines with potassium and ammonium carbonate were obtained were obtained.
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