|
|
| Type |
Symposium |
| Area |
Recent Trends in Drug Discovery |
| Room No. |
Room 302 |
| Time |
THU 15:40-: |
| Code |
MEDI-1 |
| Subject |
Considerations for the Design of Chimeric Antigen Receptor |
| Authors |
Chan Hyuk Kim
Department of Biological Sciences, KAIST, Korea |
| Abstract |
Since the concept of chimeric antigen receptor (CAR) was first introduced by Eshhar and coworkers as “T-body” in 1980s, several structural refinements have been made to further increase the potency of the engineered T cells. As a result, adoptive transfer of CAR-T cells has been showing impressive results in recent clinical trials, in particular for the patients suffering with refractory hematologic malignancies. In this talk, I will briefly review some of the important preclinical and clinical papers that describe how each structural component of CAR (i.e. targeting, spacer, transmembrane, and intracellular signaling domains) affect the activity and specificity of engineered T cells, and discuss considerations for the design of an optimal CAR. |
| E-mail |
kimchanhyuk@kaist.ac.kr |
|
121st General Meeting of the KCS