121st General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Material Chemists
Room No. Samda Hall A
Time THU 09:55-:
Code MAT.O-6
Subject High Tumor Targeting and Neutron Capture Efficiencies of BSH-LDH in Boron Neutron Capture Therapy
Authors GOEUN CHOI, HUIYAN PIAO, SAIRAN EOM, JIN-HO CHOY*
Department of Chemistry and Nano Science, Ewha Womans University, Korea
Abstract An attempt was made to apply layered double hydroxide (LDH) as a boron delivery carrier for boron neutron capture therapy (BNCT), which needs a sufficient amount of boron in tumor cells for its successful administration. To meet this requirement, a nanohybrid (BSH-LDH), mercaptoundecahydro-closo-dodecaborate (BSH) anionic molecules in LDH, was developed as a boron delivery system. The cellular boron content upon permeation of BSH-LDH nanoparticles (42.4 μg 10B/106 cells) in U87 glioblastoma cell line was found to be ~ 2000 times larger than the minimum boron requirement (~ 0.02 μg 10B/106 cells) for BNCT, and also orders of magnitude higher than the previous results (0.2 ~ 1.5 μg 10B/106 cells) by those applied with other targeting strategies, and eventually resulted in excellent neutron capture efficiency even under such low dose (30 μg 10B/mL) and weak irradiation (1 x 1012 n/cm2 corresponding to 20 min) condition. According to the biodistribution studies in xenograft mice model, the tumor-to-blood ratio of BSH in the BSH-LDH-treated-group was found to be 4.4-fold higher than that in the intact BSH treated one in 2 hours after drug treatment. The present BNCT combined with boron delivery system could provide a promising integrative therapeutic platform for cancer treatment.
E-mail goeun.choi@ewha.ac.kr