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| Type |
Oral Presentation |
| Area |
Oral Presentation of Young Material Chemists |
| Room No. |
Samda Hall A |
| Time |
THU 10:50-: |
| Code |
MAT.O-11 |
| Subject |
64Cu-doped layered double hydroxide for in-vivo PET imaging agent |
| Authors |
SAIRAN EOM, GOEUN CHOI, JIN-HO CHOY*
Department of Chemistry and Nano Science, Ewha Womans University, Korea
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| Abstract |
Copper-64 (64Cu), a positron-emitting radionuclide, has been widely used as a imaging radioisotope for positron emission tomography (PET), due to its low energy (653 keV) and long half-life of 12.7 h. Recently, we have developed a PET imaging nanoparticle, a biocompatible and stable 64Cu - layered double hydroxide (64Cu-LDH) for systemic delivery, by co-precipitation and hydrothermal method. According to the XRD and SEM studies, the 64Cu-LDH maintained its lamella structure with plate-like morphology. And it showed its 64Cu labeling efficiency of 99%. The doped 64Cu was well incorporated into octahedral site of LDH lattice, and as a consequence, the 64Cu-LDH was found to be chemically very stable not only in saline and PBS, but also in biological media such as mouse and human serums. Small animal PET images of the 64Cu-LDH were obtained from 2 h to 48 h after i.v. injection in MDA-MB-231 xenograft mouse model, indicating that its tumor selectivity was increased by time. To enhance tumor uptake efficiency, the 64Cu-LDH covered with bovine serum albumin (BSA) were attampted for PET imaging. And surprisingly, we found that the 64Cu-LDH-BSA showed 2-fold higher tumor uptake efficiency compared to the 64Cu-LDH. According to our previous drug delivery system (DDS) studies, we have already demonstrated that drug-LDH could be permeated inside the cells very efficiently through the clathrin mediated endocytosis, resulting in enhanced therapeutic efficacy than free drug in tumor-bearing mouse model. It is, therefore, concluded that the 64Cu-LDH could be a promising material not only as the drug delivery carrier for cancer therapy, but also as the imaging and diagnostic agents. |
| E-mail |
denbeo@naver.com |
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121st General Meeting of the KCS